Describe pratiloma samprapti of rajyakshma.

• A. Depletion of Ojas Leading to Retrograde Depletion of Tissues Starting at Ojas
• B. Depletion of Rasa Dhatu
• C. Accumulation of Vata
• D. Obstruction of Channels

Answer: (A)

The main idea tested is pratiloma samprapti in rajyakshma, which describes a reverse progression of tissue depletion starting from Ojas. Ojas is treated in Ayurveda as the refined essence that sustains immunity and the nourishment of all dhatus. When Ojas becomes depleted, the body’s capacity to nourish the subsequent tissues diminishes, and the dhatu depletion proceeds in the opposite order of their normal nourishment. So, as Ojas wanes, the next affected tissue is Rasa, then Rakta, followed by Mamsa, Meda, Asthi, Majja, and Shukra. This retrograde cascade explains the wasting and protracted debility seen in rajyakshma.

Depletion of Rasa Dhatu alone would not capture the initiating step, because the concept emphasizes Ojas as the starting point of the process. Accumulation of Vata or obstruction of channels are not the defining mechanism here; they may be involved in broader disease features but do not describe the reverse, Ojas-centered progression that characterizes pratiloma samprapti.